Efficacy of prophylactic methylprednisolone on reducing the risk of post-extubation stridor in patients after an emergency intubation: study protocol for a randomized controlled trial

Abstract Background Post-extubation stridor (PES) is one of the most common complications invasive respiratory support, with severe cases leading to possible extubation failure (reintubation within 48 h) and increased mortality. Previous studies confirmed that prophylactic corticosteroids play an important role in reducing risk PES failure. However, few have looked at efficacy on preventing patients after emergency intubation. Aim To evaluate whether a single dose methylprednisolone given over set timeframe before effective Methods A multicenter, randomized, placebo-controlled trial will be performed department (ED) setting. The include 132 who fail cuff-leak test (CLT) prior intervention. Patients randomly assigned either intravenous (40 mg) or placebo 4 h extubation. Other eligible pass CLT included non-intervention (observation) group. primary endpoint incidence Secondary endpoints oxygen therapy, support requirements, reintubation secondary PES, adverse effects extubation, hospital length stay, Discussion are intubated basis higher intubation-related complications. examined treatment regimens involving more than 10 different variations corticosteroid treatments for prevention, while ED only simple would appropriate. Corticosteroid administration usually accompanied by effects; thus, this study further stratification among patients. Trial registration Chictr.org.cn ChiCTR2000030349 . Registered 29 February 2020.